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Health
conditions
A brain abscess is formed, when there is localized collection of pus, in
a cavity formed by the breakdown of the tissue, in the brain. The causative
agents of brain abscess include bacteria, fungi and parasites. Amongst the
fungi, Aspergillus and Candida species and Cryptococcus
neoformans are the common agents of brain abscess.
Pseudallescheria boydii (P. boydii) is listed as the causative
agent of mycetoma but can cause infections elsewhere in immunocompromised
hosts. P. boydii is a natural inhabitant of soil, manure and polluted
water. Route of infection to central nervous system (CNS) is aspiration of
the fungus to the lungs producing pulmonary infection and then leading to
dissemination of the fungus to the brain. Alternatively, this fungus can
gain entry through fracture in the skull or paranasal sinuses.
P. boydii infection of the CNS carries a high mortality. Out of 20 cases
described in world literature only four patients have survived. -
Bombay Hospital Journal
Antifungal therapy for P. boydii is complicated because most strains are
resistant to amphotericin-B. Therefore the drug of choice is miconazole or
ketoconazole.
Acknowledgment The mycological information gathered and organized in
this extensive research on different pathogenic moulds was sourced
from the informative websites listed below:
Bombay Hospital Journal
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